Sintesis de imidazoles pdf

The group includes metronidazole flagyl, mebendazole, thiabendazole tiabendazole, clotrimazole canesten, ketoconazole and miconazole. Starting from 1,2diketones and urotropine in the presence of ammonium acetate, a simple and efficient solventless microwaveassisted enabled the synthesis of 4,5disubstituted imidazoles. Pinto who passed away in 2010, a great scientist and our mentor in all aspects. A class of antifungal and antibacterial drugs effective against a wide range of bacteria and fungi. In step one the diketone and ammonia form an diimine. The debusradziszewski imidazole synthesis is an organic reaction used for the synthesis of imidazoles from a dicarbonyl, an aldehyde, and ammonia. A group of antifungal drugs, used mainly to treat infections of the skin and mucous membranes.

Imidazoles definition of imidazoles by the free dictionary. The dicarbonyl component is commonly glyoxal, but can also include various 1,2diketones and ketoaldehydes. The baran group synthesis of imidazoles alexandros zografos meeting indroduction. Debusradziszewski imidazole synthesis project gutenberg. A nhccoppercatalyzed isocyanide insertion into alcohol to form an n arylformimidate intermediate and subsequent. Pdf on may 1, 2006, guillermo mendoza diaz and others published sintesis. An efficient and robust catalytic system for the fluorine. Planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. The process is an example of a multicomponent reaction. Miconazole has a wide antifungal spectrum against most fungi and yeasts of veterinary interest. Sensitive organisms include blastomyces dermatitidis, paracoccidioides brasiliensis, histoplasma capsulatum, candida spp, coccidioides immitis, cryptococcus neoformans, and aspergillus fumigatus. This paper is dedicated to the memory of professor antonio v. The lowmelting mixture ureazncl 2 as reaction medium efficiently catalyzes the formation of imidazoles from a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde to provide a broad range of triaryl1h imidazoles or 2aryl1hphenanthro9,10d imidazoles in very good yields.

Named first as gluoxaline first synthesis with glyoxal and ammonia. The antifungal imidazoles also have some antibacterial action but are rarely used for this purpose. Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against mycobacterium tuberculosis. Imidazoles definition of imidazoles by medical dictionary. The debusradziszewski imidazole synthesis is an organic reaction describing the synthesis of an imidazole from a diketone, an aldehyde and ammonia.